Assay Detail
Functional
CHEMBL923943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of doxorubicin-induced cell cycle arrest at G2/M phase in H1299 cells by FACS
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.81 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398750 | — | — | 1 | 6.52 |
| CHEMBL245802 | — | — | 1 | 6.52 |
| CHEMBL247026 | — | — | 1 | 6.17 |
| CHEMBL247396 | — | — | 1 | 6.16 |
| CHEMBL445410 | — | — | 1 | 5.89 |
| CHEMBL247201 | — | — | 1 | 5.89 |
| CHEMBL396372 | — | — | 1 | 5.89 |
| CHEMBL395894 | — | — | 1 | 5.89 |
| CHEMBL399254 | — | — | 1 | 5.85 |
| CHEMBL247590 | — | — | 1 | 5.72 |
| CHEMBL399532 | — | — | 1 | 5.68 |
| CHEMBL247588 | — | — | 1 | 5.58 |
| CHEMBL400893 | — | — | 1 | 5.57 |
| CHEMBL400689 | — | — | 1 | 5.57 |
| CHEMBL440959 | — | — | 1 | 5.38 |
| CHEMBL248395 | — | — | 1 | 5.32 |
| CHEMBL248396 | — | — | 1 | 5.21 |
| CHEMBL245605 | — | — | 1 | - |
| CHEMBL397313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398750 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL245802 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL247026 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL247396 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL445410 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL247201 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL396372 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL395894 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL399254 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL247590 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL399532 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL247588 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL400893 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL400689 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL440959 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL248395 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL248396 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL245605 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL397313 | — | EC50 | > | 10000.0 | nM | - |