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Assay Detail

CHEMBL923980

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Binding
Inhibition of Escherichia coli DXR
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors.
Devreux V, Wiesner J, Jomaa H, Van der Eycken J, Van Calenbergh S.
Bioorg Med Chem Lett (2007) 17 : 4920 -4923
PubMed 17583502 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.86 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL205338 FR-900098 1 7.50
CHEMBL203125 FOSMIDOMYCIN 3.0 1 7.47
CHEMBL204106 1 7.23
CHEMBL250929 1 6.35
CHEMBL399374 1 5.26
CHEMBL250733 1 5.24
CHEMBL250734 1 4.80
CHEMBL250731 1 4.47
CHEMBL401185 1 4.38
CHEMBL250732 1 -
CHEMBL250531 1 -
CHEMBL249099 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL205338 FR-900098 IC50 = 32.0 nM 7.50
CHEMBL203125 FOSMIDOMYCIN IC50 = 34.0 nM 7.47
CHEMBL204106 IC50 = 59.0 nM 7.23
CHEMBL250929 IC50 = 450.0 nM 6.35
CHEMBL399374 IC50 = 5500.0 nM 5.26
CHEMBL250733 IC50 = 5700.0 nM 5.24
CHEMBL250734 IC50 = 16000.0 nM 4.80
CHEMBL250731 IC50 = 34000.0 nM 4.47
CHEMBL401185 IC50 = 42000.0 nM 4.38
CHEMBL250732 IC50 > 30000.0 nM -
CHEMBL250531 IC50 > 30000.0 nM -
CHEMBL249099 IC50 > 30000.0 nM -