Assay Detail
Binding
CHEMBL924052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC6
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.24 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.28 |
| CHEMBL247217 | — | — | 1 | 6.64 |
| CHEMBL247654 | — | — | 1 | 6.55 |
| CHEMBL247653 | — | — | 1 | 6.12 |
| CHEMBL247218 | — | — | 1 | 6.00 |
| CHEMBL246199 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL247217 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL247654 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL247653 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL247218 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL246199 | — | IC50 | = | 15000.0 | nM | 4.82 |