Assay Detail
Functional
CHEMBL924432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of camptothecin induced mitotic arrest in human NCI-H1299 cells after 18 hrs
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.71 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249429 | — | — | 1 | 7.85 |
| CHEMBL400350 | — | — | 1 | 7.36 |
| CHEMBL249443 | — | — | 1 | 7.33 |
| CHEMBL249224 | — | — | 1 | 7.19 |
| CHEMBL249441 | — | — | 1 | 7.17 |
| CHEMBL428409 | — | — | 1 | 7.10 |
| CHEMBL400127 | — | — | 1 | 7.00 |
| CHEMBL250035 | — | — | 1 | 6.89 |
| CHEMBL249237 | — | — | 1 | 6.89 |
| CHEMBL249044 | — | — | 1 | 6.85 |
| CHEMBL249240 | — | — | 1 | 6.85 |
| CHEMBL400323 | — | — | 1 | 6.82 |
| CHEMBL401156 | — | — | 1 | 6.68 |
| CHEMBL249241 | — | — | 1 | 6.64 |
| CHEMBL249594 | — | — | 1 | 6.64 |
| CHEMBL250459 | — | — | 1 | 6.57 |
| CHEMBL249834 | — | — | 1 | 6.52 |
| CHEMBL249595 | — | — | 1 | 6.51 |
| CHEMBL250272 | — | — | 1 | 6.50 |
| CHEMBL249632 | — | — | 1 | 6.43 |
| CHEMBL250033 | — | — | 1 | 6.43 |
| CHEMBL428580 | — | — | 1 | 6.02 |
| CHEMBL248665 | — | — | 1 | 5.98 |
| CHEMBL249236 | — | — | 1 | 5.96 |
| CHEMBL250224 | — | — | 1 | 5.66 |
| CHEMBL249238 | — | — | 1 | - |
| CHEMBL250225 | — | — | 1 | - |
| CHEMBL250222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249429 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL400350 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL249443 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL249224 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL249441 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL428409 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL400127 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL250035 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL249237 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL249044 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL249240 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL400323 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL401156 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL249241 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL249594 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL250459 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL249834 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL249595 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL250272 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL249632 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL250033 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL428580 | — | EC50 | = | 957.0 | nM | 6.02 |
| CHEMBL248665 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL249236 | — | EC50 | = | 1085.0 | nM | 5.96 |
| CHEMBL250224 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL249238 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL250225 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL250222 | — | EC50 | - | — | - |