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Assay Detail

CHEMBL924503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of cathepsin L by fluorescence assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel scaffold for cathepsin K inhibitors.
Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C.
Bioorg Med Chem Lett (2007) 17 : 6096 -6100
PubMed 17911019 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 6.60 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL249367 1 7.09
CHEMBL250589 1 7.02
CHEMBL250591 1 6.96
CHEMBL398719 1 6.96
CHEMBL249157 1 6.92
CHEMBL250990 1 6.85
CHEMBL250181 1 6.77
CHEMBL430017 1 6.58
CHEMBL249979 1 6.42
CHEMBL398718 1 6.39
CHEMBL251569 1 6.37
CHEMBL251571 1 6.28
CHEMBL250590 1 6.27
CHEMBL400491 1 6.11
CHEMBL398953 1 6.01
CHEMBL399054 1 -
CHEMBL249759 1 -
CHEMBL249758 1 -
CHEMBL249757 1 -
CHEMBL250165 1 -
CHEMBL248539 1 -
CHEMBL251570 1 -
CHEMBL413988 1 -
CHEMBL399842 1 -
CHEMBL251186 1 -
CHEMBL250989 1 -
CHEMBL251187 1 -
CHEMBL250793 1 -
CHEMBL398519 1 -
CHEMBL249564 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL249367 IC50 = 82.0 nM 7.09
CHEMBL250589 IC50 = 96.0 nM 7.02
CHEMBL250591 IC50 = 110.0 nM 6.96
CHEMBL398719 IC50 = 110.0 nM 6.96
CHEMBL249157 IC50 = 120.0 nM 6.92
CHEMBL250990 IC50 = 140.0 nM 6.85
CHEMBL250181 IC50 = 170.0 nM 6.77
CHEMBL430017 IC50 = 260.0 nM 6.58
CHEMBL249979 IC50 = 380.0 nM 6.42
CHEMBL398718 IC50 = 410.0 nM 6.39
CHEMBL251569 IC50 = 430.0 nM 6.37
CHEMBL251571 IC50 = 520.0 nM 6.28
CHEMBL250590 IC50 = 540.0 nM 6.27
CHEMBL400491 IC50 = 770.0 nM 6.11
CHEMBL398953 IC50 = 970.0 nM 6.01
CHEMBL400395 IC50 > 1000.0 nM -
CHEMBL249966 IC50 > 1000.0 nM -
CHEMBL249965 IC50 > 1000.0 nM -
CHEMBL399054 IC50 > 1000.0 nM -
CHEMBL249759 IC50 > 1000.0 nM -
CHEMBL249758 IC50 > 1000.0 nM -
CHEMBL249757 IC50 > 1000.0 nM -
CHEMBL250165 IC50 > 1000.0 nM -
CHEMBL248539 IC50 > 1000.0 nM -
CHEMBL251570 IC50 > 1000.0 nM -
CHEMBL413988 IC50 > 1000.0 nM -
CHEMBL399842 IC50 > 1000.0 nM -
CHEMBL251186 IC50 > 1000.0 nM -
CHEMBL250989 IC50 > 1000.0 nM -
CHEMBL251187 IC50 > 1000.0 nM -
CHEMBL250793 IC50 > 1000.0 nM -
CHEMBL398519 IC50 > 1000.0 nM -
CHEMBL249564 IC50 > 1000.0 nM -