Assay Detail
Binding
CHEMBL924745
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Inhibition of GAL4-tagged NR5A1 by luciferase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.07 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408947 | — | — | 1 | 6.96 |
| CHEMBL265938 | — | — | 1 | 6.72 |
| CHEMBL410467 | — | — | 1 | 6.70 |
| CHEMBL262079 | — | — | 1 | 6.70 |
| CHEMBL408702 | — | — | 1 | 6.58 |
| CHEMBL412079 | — | — | 1 | 6.47 |
| CHEMBL412080 | — | — | 1 | 6.44 |
| CHEMBL411889 | — | — | 1 | 6.44 |
| CHEMBL260592 | — | — | 1 | 6.28 |
| CHEMBL260420 | — | — | 1 | 6.23 |
| CHEMBL261115 | — | — | 1 | 6.17 |
| CHEMBL259067 | — | — | 1 | 6.12 |
| CHEMBL261114 | — | — | 1 | 5.97 |
| CHEMBL261305 | — | — | 1 | 5.75 |
| CHEMBL408704 | — | — | 1 | 5.45 |
| CHEMBL261113 | — | — | 1 | 5.33 |
| CHEMBL411501 | — | — | 1 | 5.07 |
| CHEMBL260545 | — | — | 1 | 5.01 |
| CHEMBL260419 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408947 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL265938 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL410467 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL262079 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL408702 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL412079 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL412080 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL411889 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL260592 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL260420 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL261115 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL259067 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL261114 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL261305 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL408704 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL261113 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL411501 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL260545 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL260419 | — | IC50 | = | 13700.0 | nM | 4.86 |