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Assay Detail

CHEMBL924919

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Binding
Inhibition of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase after 5 mins by HPAEC-PED method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Arthrobacter protophormiae
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Endo-beta-N-acetylglucosaminidase (CHEMBL1075042)
Type SINGLE PROTEIN
Organism Arthrobacter protophormiae

Publication

Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-beta-N-acetylglucosaminidases.
Li B, Takegawa K, Suzuki T, Yamamoto K, Wang LX.
Bioorg Med Chem (2008) 16 : 4670 -4675
PubMed 18304822 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.32 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL259756 1 6.66
CHEMBL261523 1 4.89
CHEMBL260584 1 4.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL259756 IC50 = 220.0 nM 6.66
CHEMBL261523 IC50 = 13000.0 nM 4.89
CHEMBL260584 IC50 = 38000.0 nM 4.42