Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL924950

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP2
ChEMBL ↗
126
Total Activities
126
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

72 kDa type IV collagenase (CHEMBL333) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Verma RP, Hansch C.
Bioorg Med Chem (2007) 15 : 2223 -2268
PubMed 17275314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 88 7.19 9.70
Ki 38 8.12 9.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL347595 — — 1 9.70
CHEMBL318860 — — 1 9.59
CHEMBL20154 — — 1 9.47
CHEMBL154551 — — 1 9.42
CHEMBL294066 — — 1 9.22
CHEMBL123775 — — 1 9.16
CHEMBL293503 — — 1 9.16
CHEMBL269019 — — 1 9.15
CHEMBL98770 — — 1 9.10
CHEMBL306726 — — 1 9.10
CHEMBL340461 — — 1 9.10
CHEMBL332755 — — 1 9.10
CHEMBL123463 — — 1 9.05
CHEMBL59722 — — 1 9.00
CHEMBL154317 — — 1 9.00
CHEMBL62245 — — 1 9.00
CHEMBL62056 — — 1 9.00
CHEMBL7108 — — 1 9.00
CHEMBL7390 — — 1 9.00
CHEMBL157112 — — 1 8.89
CHEMBL122836 — — 1 8.85
CHEMBL122711 — — 1 8.85
CHEMBL432223 — — 1 8.82
CHEMBL55110 — — 1 8.82
CHEMBL262676 — — 1 8.82
CHEMBL350231 — — 1 8.80
CHEMBL331311 — — 1 8.72
CHEMBL60546 — — 1 8.70
CHEMBL330857 — — 1 8.62
CHEMBL304281 — — 1 8.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL347595 — IC50 = 0.1995 nM 9.70
CHEMBL318860 — IC50 = 0.257 nM 9.59
CHEMBL20154 — IC50 = 0.3388 nM 9.47
CHEMBL154551 — IC50 = 0.3802 nM 9.42
CHEMBL294066 — IC50 = 0.6026 nM 9.22
CHEMBL123775 — Ki = 0.6918 nM 9.16
CHEMBL293503 — Ki = 0.6918 nM 9.16
CHEMBL269019 — IC50 = 0.7079 nM 9.15
CHEMBL98770 — IC50 = 0.7943 nM 9.10
CHEMBL332755 — Ki = 0.7943 nM 9.10
CHEMBL306726 — Ki = 0.7943 nM 9.10
CHEMBL340461 — Ki = 0.7943 nM 9.10
CHEMBL123463 — Ki = 0.8913 nM 9.05
CHEMBL7108 — IC50 = 1.0 nM 9.00
CHEMBL154317 — IC50 = 1.0 nM 9.00
CHEMBL62245 — IC50 = 1.0 nM 9.00
CHEMBL62056 — IC50 = 1.0 nM 9.00
CHEMBL59722 — IC50 = 1.0 nM 9.00
CHEMBL7390 — IC50 = 1.0 nM 9.00
CHEMBL157112 — IC50 = 1.288 nM 8.89
CHEMBL122836 — Ki = 1.413 nM 8.85
CHEMBL122711 — Ki = 1.413 nM 8.85
CHEMBL262676 — Ki = 1.514 nM 8.82
CHEMBL432223 — Ki = 1.514 nM 8.82
CHEMBL55110 — Ki = 1.514 nM 8.82
CHEMBL350231 — IC50 = 1.585 nM 8.80
CHEMBL331311 — Ki = 1.905 nM 8.72
CHEMBL60546 — IC50 = 1.995 nM 8.70
CHEMBL330857 — Ki = 2.399 nM 8.62
CHEMBL304281 — Ki = 2.884 nM 8.54
CHEMBL123041 — Ki = 3.236 nM 8.49
CHEMBL157163 — IC50 = 3.311 nM 8.48
CHEMBL251440 — IC50 = 3.388 nM 8.47
CHEMBL152855 — IC50 = 3.388 nM 8.47
CHEMBL122719 — Ki = 3.715 nM 8.43
CHEMBL122831 — Ki = 3.715 nM 8.43
CHEMBL441084 — Ki = 3.89 nM 8.41
CHEMBL11306 — IC50 = 3.981 nM 8.40
CHEMBL268377 — IC50 = 5.248 nM 8.28
CHEMBL152592 — IC50 = 5.754 nM 8.24
CHEMBL345445 — IC50 = 6.457 nM 8.19
CHEMBL6973 — IC50 = 8.71 nM 8.06
CHEMBL318005 — IC50 = 10.0 nM 8.00
CHEMBL331342 — Ki = 10.0 nM 8.00
CHEMBL58945 — IC50 = 10.0 nM 8.00
CHEMBL152805 — IC50 = 10.96 nM 7.96
CHEMBL99547 — IC50 = 10.96 nM 7.96
CHEMBL311336 — Ki = 10.96 nM 7.96
CHEMBL440714 — Ki = 12.02 nM 7.92
CHEMBL99120 — IC50 = 12.88 nM 7.89