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Assay Detail

CHEMBL924952

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Binding
Inhibition of MMP13
ChEMBL ↗
79
Total Activities
79
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Collagenase 3 (CHEMBL280) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Verma RP, Hansch C.
Bioorg Med Chem (2007) 15 : 2223 -2268
PubMed 17275314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 73 7.88 9.40
Ki 6 8.70 9.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL178163 — — 1 9.48
CHEMBL253680 — — 1 9.40
CHEMBL82169 — — 1 9.15
CHEMBL125598 — — 1 9.05
CHEMBL180616 — — 1 9.02
CHEMBL332302 — — 1 9.00
CHEMBL252462 — — 1 9.00
CHEMBL80272 — — 1 9.00
CHEMBL83368 — — 1 9.00
CHEMBL311004 — — 1 9.00
CHEMBL315114 — — 1 9.00
CHEMBL90978 — — 1 8.89
CHEMBL340923 — — 1 8.82
CHEMBL123615 — — 1 8.77
CHEMBL83282 — — 1 8.74
CHEMBL331095 — — 1 8.72
CHEMBL338077 — — 1 8.66
CHEMBL327621 — — 1 8.66
CHEMBL312100 — — 1 8.62
CHEMBL123627 — — 1 8.60
CHEMBL180275 — — 1 8.57
CHEMBL421644 — — 1 8.52
CHEMBL253261 — — 1 8.52
CHEMBL311266 — — 1 8.46
CHEMBL369302 — — 1 8.40
CHEMBL76974 — — 1 8.40
CHEMBL361527 — — 1 8.39
CHEMBL359716 — — 1 8.38
CHEMBL327442 — — 1 8.34
CHEMBL178509 — — 1 8.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL178163 — Ki = 0.3311 nM 9.48
CHEMBL253680 — IC50 = 0.3981 nM 9.40
CHEMBL82169 — IC50 = 0.7079 nM 9.15
CHEMBL125598 — IC50 = 0.8913 nM 9.05
CHEMBL180616 — Ki = 0.955 nM 9.02
CHEMBL332302 — IC50 = 1.0 nM 9.00
CHEMBL252462 — IC50 = 1.0 nM 9.00
CHEMBL80272 — IC50 = 1.0 nM 9.00
CHEMBL83368 — IC50 = 1.0 nM 9.00
CHEMBL311004 — IC50 = 1.0 nM 9.00
CHEMBL315114 — IC50 = 1.0 nM 9.00
CHEMBL90978 — IC50 = 1.288 nM 8.89
CHEMBL340923 — IC50 = 1.514 nM 8.82
CHEMBL123615 — IC50 = 1.698 nM 8.77
CHEMBL83282 — IC50 = 1.82 nM 8.74
CHEMBL331095 — IC50 = 1.905 nM 8.72
CHEMBL338077 — IC50 = 2.188 nM 8.66
CHEMBL327621 — IC50 = 2.188 nM 8.66
CHEMBL312100 — IC50 = 2.399 nM 8.62
CHEMBL123627 — IC50 = 2.512 nM 8.60
CHEMBL180275 — Ki = 2.692 nM 8.57
CHEMBL421644 — IC50 = 3.02 nM 8.52
CHEMBL253261 — IC50 = 3.02 nM 8.52
CHEMBL311266 — IC50 = 3.467 nM 8.46
CHEMBL76974 — IC50 = 3.981 nM 8.40
CHEMBL369302 — IC50 = 3.981 nM 8.40
CHEMBL361527 — Ki = 4.074 nM 8.39
CHEMBL359716 — Ki = 4.169 nM 8.38
CHEMBL327442 — IC50 = 4.571 nM 8.34
CHEMBL178509 — Ki = 4.677 nM 8.33
CHEMBL359502 — IC50 = 5.012 nM 8.30
CHEMBL252461 — IC50 = 5.129 nM 8.29
CHEMBL83955 — IC50 = 5.37 nM 8.27
CHEMBL80300 — IC50 = 6.026 nM 8.22
CHEMBL329558 — IC50 = 6.166 nM 8.21
CHEMBL402745 — IC50 = 6.918 nM 8.16
CHEMBL183132 — IC50 = 7.079 nM 8.15
CHEMBL97936 — IC50 = 7.943 nM 8.10
CHEMBL70176 — IC50 = 7.943 nM 8.10
CHEMBL100100 — IC50 = 7.943 nM 8.10
CHEMBL361959 — IC50 = 8.913 nM 8.05
CHEMBL329313 — IC50 = 10.0 nM 8.00
CHEMBL328255 — IC50 = 10.96 nM 7.96
CHEMBL79267 — IC50 = 13.8 nM 7.86
CHEMBL253904 — IC50 = 15.85 nM 7.80
CHEMBL313168 — IC50 = 16.98 nM 7.77
CHEMBL181208 — IC50 = 16.98 nM 7.77
CHEMBL329298 — IC50 = 19.95 nM 7.70
CHEMBL178732 — IC50 = 19.95 nM 7.70
CHEMBL328162 — IC50 = 19.95 nM 7.70