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Assay Detail

CHEMBL924953

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Binding
Inhibition of MMP14
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Matrix metalloproteinase-14 (CHEMBL3869)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Verma RP, Hansch C.
Bioorg Med Chem (2007) 15 : 2223 -2268
PubMed 17275314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.21 7.80
Ki 5 6.63 7.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL252067 1 7.80
CHEMBL252267 1 7.74
CHEMBL403648 1 7.72
CHEMBL252269 1 7.64
CHEMBL222002 1 7.64
CHEMBL398271 1 7.59
CHEMBL403649 1 7.44
CHEMBL252464 1 7.30
CHEMBL437793 1 7.22
CHEMBL252465 1 7.15
CHEMBL251253 1 7.04
CHEMBL252268 1 6.92
CHEMBL252466 1 6.82
CHEMBL252867 1 6.70
CHEMBL252665 1 6.66
CHEMBL438692 1 6.57
CHEMBL403647 1 6.29
CHEMBL428233 1 6.26
CHEMBL404715 1 6.21
CHEMBL252868 1 6.19
CHEMBL400346 1 5.69
CHEMBL252664 1 5.17
CHEMBL252666 1 5.06
CHEMBL404716 1 5.03
CHEMBL198039 1 4.91
CHEMBL198262 1 4.82
CHEMBL425020 1 4.82
CHEMBL427366 1 4.80
CHEMBL199241 1 4.52
CHEMBL194377 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL252067 IC50 = 15.85 nM 7.80
CHEMBL252267 IC50 = 18.2 nM 7.74
CHEMBL403648 IC50 = 19.05 nM 7.72
CHEMBL252269 IC50 = 22.91 nM 7.64
CHEMBL222002 IC50 = 22.91 nM 7.64
CHEMBL398271 Ki = 25.7 nM 7.59
CHEMBL403649 IC50 = 36.31 nM 7.44
CHEMBL252464 IC50 = 50.12 nM 7.30
CHEMBL437793 IC50 = 60.26 nM 7.22
CHEMBL252465 IC50 = 70.79 nM 7.15
CHEMBL251253 Ki = 91.2 nM 7.04
CHEMBL252268 IC50 = 120.23 nM 6.92
CHEMBL252466 IC50 = 151.36 nM 6.82
CHEMBL252867 IC50 = 199.53 nM 6.70
CHEMBL252665 IC50 = 218.78 nM 6.66
CHEMBL438692 Ki = 269.15 nM 6.57
CHEMBL403647 IC50 = 512.86 nM 6.29
CHEMBL428233 Ki = 549.54 nM 6.26
CHEMBL404715 IC50 = 616.6 nM 6.21
CHEMBL252868 IC50 = 645.65 nM 6.19
CHEMBL400346 Ki = 2041.74 nM 5.69
CHEMBL252664 IC50 = 6760.83 nM 5.17
CHEMBL252666 IC50 = 8709.64 nM 5.06
CHEMBL404716 IC50 = 9332.54 nM 5.03
CHEMBL198039 IC50 = 12302.69 nM 4.91
CHEMBL198262 IC50 = 15135.61 nM 4.82
CHEMBL425020 IC50 = 15135.61 nM 4.82
CHEMBL427366 IC50 = 15848.93 nM 4.80
CHEMBL199241 IC50 = 30199.52 nM 4.52
CHEMBL194377 IC50 = 30199.52 nM 4.52
CHEMBL194430 IC50 = 50118.72 nM 4.30