Assay Detail
Binding
CHEMBL924958
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Inhibition of MMP3
114
Total Activities
114
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 73 | 7.01 | 9.30 |
| Ki | 41 | 6.54 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154044 | — | — | 1 | 9.30 |
| CHEMBL140970 | — | — | 1 | 9.15 |
| CHEMBL345447 | — | — | 1 | 8.59 |
| CHEMBL436205 | — | — | 1 | 8.57 |
| CHEMBL156830 | — | — | 1 | 8.42 |
| CHEMBL347595 | — | — | 1 | 8.36 |
| CHEMBL117225 | — | — | 1 | 8.23 |
| CHEMBL86797 | — | — | 1 | 8.22 |
| CHEMBL139884 | — | — | 1 | 8.18 |
| CHEMBL350231 | — | — | 1 | 8.17 |
| CHEMBL342210 | — | — | 1 | 8.16 |
| CHEMBL100100 | — | — | 1 | 8.15 |
| CHEMBL152277 | — | — | 1 | 8.14 |
| CHEMBL154440 | — | — | 1 | 8.06 |
| CHEMBL154551 | — | — | 1 | 8.05 |
| CHEMBL443818 | — | — | 1 | 8.00 |
| CHEMBL140511 | — | — | 1 | 8.00 |
| CHEMBL140569 | — | — | 1 | 7.96 |
| CHEMBL154317 | — | — | 1 | 7.89 |
| CHEMBL153882 | — | — | 1 | 7.89 |
| CHEMBL59023 | — | — | 1 | 7.85 |
| CHEMBL87229 | — | — | 1 | 7.82 |
| CHEMBL344828 | — | — | 1 | 7.77 |
| CHEMBL157163 | — | — | 1 | 7.74 |
| CHEMBL8474 | — | — | 1 | 7.74 |
| CHEMBL157112 | — | — | 1 | 7.72 |
| CHEMBL85806 | — | — | 1 | 7.72 |
| CHEMBL152592 | — | — | 1 | 7.68 |
| CHEMBL152531 | — | — | 1 | 7.66 |
| CHEMBL153446 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154044 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL140970 | — | IC50 | = | 0.7079 | nM | 9.15 |
| CHEMBL345447 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL436205 | — | IC50 | = | 2.692 | nM | 8.57 |
| CHEMBL156830 | — | IC50 | = | 3.802 | nM | 8.42 |
| CHEMBL347595 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL117225 | — | IC50 | = | 5.888 | nM | 8.23 |
| CHEMBL86797 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL139884 | — | IC50 | = | 6.607 | nM | 8.18 |
| CHEMBL350231 | — | IC50 | = | 6.761 | nM | 8.17 |
| CHEMBL342210 | — | IC50 | = | 6.918 | nM | 8.16 |
| CHEMBL100100 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL152277 | — | IC50 | = | 7.244 | nM | 8.14 |
| CHEMBL154440 | — | IC50 | = | 8.71 | nM | 8.06 |
| CHEMBL154551 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL443818 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL140511 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL140569 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL153882 | — | IC50 | = | 12.88 | nM | 7.89 |
| CHEMBL154317 | — | IC50 | = | 12.88 | nM | 7.89 |
| CHEMBL59023 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL87229 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL344828 | — | IC50 | = | 16.98 | nM | 7.77 |
| CHEMBL8474 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL157163 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL85806 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL157112 | — | IC50 | = | 19.05 | nM | 7.72 |
| CHEMBL152592 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL152531 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL343082 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL347673 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL153446 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL348878 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL410259 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL329313 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL251482 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL249449 | — | Ki | = | 36.31 | nM | 7.44 |
| CHEMBL421985 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL153914 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL356413 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL313483 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL81270 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL140720 | — | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL436230 | — | IC50 | = | 47.86 | nM | 7.32 |
| CHEMBL20154 | — | IC50 | = | 47.86 | nM | 7.32 |
| CHEMBL97936 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL316954 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL328162 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL310438 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL152855 | — | IC50 | = | 72.44 | nM | 7.14 |