Assay Detail
Binding
CHEMBL924983
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Binding affinity to PBR in human mitochondrial tissue
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.86 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401000 | — | — | 1 | 9.62 |
| CHEMBL253596 | — | — | 1 | 8.85 |
| CHEMBL253597 | — | — | 1 | 8.61 |
| CHEMBL251953 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401000 | — | Ki | = | 0.242 | nM | 9.62 |
| CHEMBL253596 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL253597 | — | Ki | = | 2.47 | nM | 8.61 |
| CHEMBL251953 | — | Ki | = | 4.5 | nM | 8.35 |