Assay Detail
Binding
CHEMBL925016
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Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of NF-kappaB derived from thalidomide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.87 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270299 | BAY-11-7085 | — | 1 | 7.00 |
| CHEMBL249211 | — | — | 1 | 6.37 |
| CHEMBL313952 | — | — | 1 | 6.28 |
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 5.90 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | 5.69 |
| CHEMBL88474 | — | — | 1 | 5.30 |
| CHEMBL90558 | — | — | 1 | 4.53 |
| CHEMBL250004 | — | — | 1 | - |
| CHEMBL249804 | — | — | 1 | - |
| CHEMBL88953 | — | — | 1 | - |
| CHEMBL424612 | — | — | 1 | - |
| CHEMBL248805 | — | — | 1 | - |
| CHEMBL248804 | — | — | 1 | - |
| CHEMBL248602 | — | — | 1 | - |
| CHEMBL248601 | — | — | 1 | - |
| CHEMBL248600 | — | — | 1 | - |
| CHEMBL91130 | — | — | 1 | - |
| CHEMBL249394 | — | — | 1 | - |
| CHEMBL248589 | — | — | 1 | - |
| CHEMBL248786 | — | — | 1 | - |
| CHEMBL89868 | — | — | 1 | - |
| CHEMBL90616 | — | — | 1 | - |
| CHEMBL89081 | — | — | 1 | - |
| CHEMBL399744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270299 | BAY-11-7085 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL249211 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL313952 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL88474 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL90558 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL250004 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL249804 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL88953 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL424612 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248805 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248804 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248602 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248601 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248600 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL91130 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL249394 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248589 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL248786 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL89868 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL90616 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL89081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL399744 | — | IC50 | > | 50000.0 | nM | - |