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Assay Detail

CHEMBL925034

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Binding
Inhibition of MMP7
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Matrilysin (CHEMBL4073)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Verma RP, Hansch C.
Bioorg Med Chem (2007) 15 : 2223 -2268
PubMed 17275314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.43 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL252509 1 6.51
CHEMBL253979 1 6.35
CHEMBL400143 1 6.07
CHEMBL437019 1 6.00
CHEMBL254389 1 5.92
CHEMBL442431 1 5.80
CHEMBL252100 1 5.74
CHEMBL400590 1 5.64
CHEMBL358539 1 5.62
CHEMBL254184 1 5.59
CHEMBL252102 1 5.59
CHEMBL148214 1 5.50
CHEMBL147881 1 5.15
CHEMBL252711 1 5.13
CHEMBL252101 1 5.12
CHEMBL252508 1 5.04
CHEMBL147882 1 4.98
CHEMBL148171 1 4.97
CHEMBL254185 1 4.96
CHEMBL400540 1 4.96
CHEMBL146718 1 4.92
CHEMBL424130 1 4.67
CHEMBL147489 1 4.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL252509 IC50 = 309.03 nM 6.51
CHEMBL253979 IC50 = 446.68 nM 6.35
CHEMBL400143 IC50 = 851.14 nM 6.07
CHEMBL437019 IC50 = 1000.0 nM 6.00
CHEMBL254389 IC50 = 1202.26 nM 5.92
CHEMBL442431 IC50 = 1584.89 nM 5.80
CHEMBL252100 IC50 = 1819.7 nM 5.74
CHEMBL400590 IC50 = 2290.87 nM 5.64
CHEMBL358539 IC50 = 2398.83 nM 5.62
CHEMBL254184 IC50 = 2570.4 nM 5.59
CHEMBL252102 IC50 = 2570.4 nM 5.59
CHEMBL148214 IC50 = 3162.28 nM 5.50
CHEMBL147881 IC50 = 7079.46 nM 5.15
CHEMBL252711 IC50 = 7413.1 nM 5.13
CHEMBL252101 IC50 = 7585.78 nM 5.12
CHEMBL252508 IC50 = 9120.11 nM 5.04
CHEMBL147882 IC50 = 10471.29 nM 4.98
CHEMBL148171 IC50 = 10715.19 nM 4.97
CHEMBL254185 IC50 = 10964.78 nM 4.96
CHEMBL400540 IC50 = 10964.78 nM 4.96
CHEMBL146718 IC50 = 12022.64 nM 4.92
CHEMBL424130 IC50 = 21379.62 nM 4.67
CHEMBL147489 IC50 = 21379.62 nM 4.67