Assay Detail
Binding
CHEMBL925064
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Inhibition of HIV1 integrase strand transfer activity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of integrase inhibitors for treatment of AIDS: an overview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 8.14 |
| CHEMBL252700 | — | — | 1 | 5.75 |
| CHEMBL252905 | — | — | 1 | 5.68 |
| CHEMBL254727 | — | — | 1 | 5.58 |
| CHEMBL404423 | — | — | 1 | 5.47 |
| CHEMBL19977 | — | — | 1 | 5.46 |
| CHEMBL49201 | — | — | 1 | 5.10 |
| CHEMBL254527 | — | — | 1 | 5.00 |
| CHEMBL32865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL252700 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL252905 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL254727 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL404423 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL19977 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL49201 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL254527 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL32865 | — | IC50 | = | 10000.0 | nM | - |