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Assay Detail

CHEMBL925135

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Binding
Inhibition of thyroid hormone receptor beta
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Thyroid hormone receptor beta (CHEMBL1947) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2D QSAR studies on thyroid hormone receptor ligands.
Valadares NF, Castilho MS, Polikarpov I, Garratt RC.
Bioorg Med Chem (2007) 15 : 4609 -4617
PubMed 17467994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 7.92 10.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291053 THYROPROPIC ACID 2.0 1 10.72
CHEMBL289343 — — 1 10.60
CHEMBL41632 TIRATRICOL 3.0 1 10.39
CHEMBL203777 — — 1 10.22
CHEMBL39174 — — 1 10.02
CHEMBL41314 — — 1 9.96
CHEMBL418432 — — 1 9.82
CHEMBL251456 — — 1 9.70
CHEMBL557 DETROTHYRONINE 2.0 1 9.58
CHEMBL425939 — — 1 9.55
CHEMBL235177 — — 1 9.33
CHEMBL235609 — — 1 9.21
CHEMBL236436 — — 1 9.11
CHEMBL442243 — — 1 9.07
CHEMBL41036 — — 1 8.96
CHEMBL235384 — — 1 8.96
CHEMBL289965 — — 1 8.68
CHEMBL235788 — — 1 8.54
CHEMBL442280 — — 1 8.49
CHEMBL236438 — — 1 8.47
CHEMBL254607 — — 1 8.46
CHEMBL393489 — — 1 8.40
CHEMBL249445 — — 1 8.38
CHEMBL238178 — — 1 8.31
CHEMBL235165 — — 1 8.22
CHEMBL235607 — — 1 8.22
CHEMBL235816 — — 1 8.17
CHEMBL235383 — — 1 8.12
CHEMBL401392 — — 1 8.07
CHEMBL392925 — — 1 8.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291053 THYROPROPIC ACID IC50 = 0.01905 nM 10.72
CHEMBL289343 — IC50 = 0.02512 nM 10.60
CHEMBL41632 TIRATRICOL IC50 = 0.04074 nM 10.39
CHEMBL203777 — IC50 = 0.06026 nM 10.22
CHEMBL39174 — IC50 = 0.0955 nM 10.02
CHEMBL41314 — IC50 = 0.1096 nM 9.96
CHEMBL418432 — IC50 = 0.1514 nM 9.82
CHEMBL251456 — IC50 = 0.1995 nM 9.70
CHEMBL557 DETROTHYRONINE IC50 = 0.263 nM 9.58
CHEMBL425939 — IC50 = 0.2818 nM 9.55
CHEMBL235177 — IC50 = 0.4677 nM 9.33
CHEMBL235609 — IC50 = 0.6166 nM 9.21
CHEMBL236436 — IC50 = 0.7762 nM 9.11
CHEMBL442243 — IC50 = 0.8511 nM 9.07
CHEMBL235384 — IC50 = 1.096 nM 8.96
CHEMBL41036 — IC50 = 1.096 nM 8.96
CHEMBL289965 — IC50 = 2.089 nM 8.68
CHEMBL235788 — IC50 = 2.884 nM 8.54
CHEMBL442280 — IC50 = 3.236 nM 8.49
CHEMBL236438 — IC50 = 3.388 nM 8.47
CHEMBL254607 — IC50 = 3.467 nM 8.46
CHEMBL393489 — IC50 = 3.981 nM 8.40
CHEMBL249445 — IC50 = 4.169 nM 8.38
CHEMBL238178 — IC50 = 4.898 nM 8.31
CHEMBL235607 — IC50 = 6.026 nM 8.22
CHEMBL235165 — IC50 = 6.026 nM 8.22
CHEMBL235816 — IC50 = 6.761 nM 8.17
CHEMBL235383 — IC50 = 7.586 nM 8.12
CHEMBL401392 — IC50 = 8.511 nM 8.07
CHEMBL392925 — IC50 = 8.511 nM 8.07
CHEMBL251090 — IC50 = 9.55 nM 8.02
CHEMBL394644 — IC50 = 10.96 nM 7.96
CHEMBL203555 — IC50 = 15.14 nM 7.82
CHEMBL250880 — IC50 = 15.14 nM 7.82
CHEMBL204609 — IC50 = 15.85 nM 7.80
CHEMBL429078 — IC50 = 18.2 nM 7.74
CHEMBL202940 — IC50 = 18.2 nM 7.74
CHEMBL40738 — IC50 = 20.89 nM 7.68
CHEMBL442082 — IC50 = 20.89 nM 7.68
CHEMBL235164 — IC50 = 28.18 nM 7.55
CHEMBL235608 — IC50 = 35.48 nM 7.45
CHEMBL237958 — IC50 = 37.15 nM 7.43
CHEMBL237722 — IC50 = 40.74 nM 7.39
CHEMBL202336 — IC50 = 44.67 nM 7.35
CHEMBL235385 — IC50 = 46.77 nM 7.33
CHEMBL205171 — IC50 = 46.77 nM 7.33
CHEMBL236648 — IC50 = 50.12 nM 7.30
CHEMBL378593 — IC50 = 51.29 nM 7.29
CHEMBL394199 — IC50 = 60.26 nM 7.22
CHEMBL238179 — IC50 = 67.61 nM 7.17