Assay Detail
Binding
CHEMBL925136
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Inhibition of human leukocyte elastase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.26 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403896 | — | — | 1 | 8.00 |
| CHEMBL437538 | — | — | 1 | 7.92 |
| CHEMBL254314 | — | — | 1 | 7.19 |
| CHEMBL443848 | — | — | 1 | 7.15 |
| CHEMBL401731 | — | — | 1 | 6.89 |
| CHEMBL401765 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403896 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL437538 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL254314 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL443848 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL401731 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL401765 | — | Ki | = | 410.0 | nM | 6.39 |