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Assay Detail

CHEMBL925155

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Binding
Binding affinity to CB1 receptor
ChEMBL ↗
79
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Cannabinoid receptor 1 (CHEMBL218) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The application of 3D-QSAR studies for novel cannabinoid ligands substituted at the C1' position of the alkyl side chain on the structural requirements for binding to cannabinoid receptors CB1 and CB2.
Durdagi S, Kapou A, Kourouli T, Andreou T, Nikas SP, Nahmias VR, Papahatjis DP, Papadopoulos MG, Mavromoustakos T.
J Med Chem (2007) 50 : 2875 -2885
PubMed 17521177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 79 7.80 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL138917 — — 1 9.70
CHEMBL476325 — — 2 9.49
CHEMBL252947 — — 1 9.47
CHEMBL199561 — — 1 9.37
CHEMBL19847 — — 2 9.36
CHEMBL108868 — — 2 9.35
CHEMBL108085 — — 2 9.28
CHEMBL325389 — — 1 9.24
CHEMBL118631 — — 2 9.15
CHEMBL411626 — — 2 9.08
CHEMBL252949 — — 1 9.03
CHEMBL120669 — — 2 8.90
CHEMBL136120 — — 1 8.82
CHEMBL336670 — — 1 8.76
CHEMBL108392 — — 2 8.74
CHEMBL239840 — — 2 8.66
CHEMBL252742 — — 1 8.57
CHEMBL398905 — — 1 8.41
CHEMBL138772 — — 1 8.35
CHEMBL434351 — — 1 8.17
CHEMBL205888 — — 2 8.08
CHEMBL252536 — — 1 7.96
CHEMBL381492 — — 2 7.93
CHEMBL119592 — — 1 7.91
CHEMBL276083 — — 1 7.85
CHEMBL118028 — — 1 7.76
CHEMBL102270 — — 1 7.72
CHEMBL67464 — — 2 7.66
CHEMBL418555 — — 2 7.66
CHEMBL206859 — — 2 7.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL138917 — Ki = 0.2 nM 9.70
CHEMBL476325 — Ki = 0.32 nM 9.49
CHEMBL476325 — Ki = 0.3236 nM 9.49
CHEMBL252947 — Ki = 0.34 nM 9.47
CHEMBL199561 — Ki = 0.43 nM 9.37
CHEMBL19847 — Ki = 0.4365 nM 9.36
CHEMBL19847 — Ki = 0.44 nM 9.36
CHEMBL108868 — Ki = 0.4467 nM 9.35
CHEMBL108868 — Ki = 0.45 nM 9.35
CHEMBL108085 — Ki = 0.5248 nM 9.28
CHEMBL108085 — Ki = 0.52 nM 9.28
CHEMBL325389 — Ki = 0.57 nM 9.24
CHEMBL118631 — Ki = 0.7079 nM 9.15
CHEMBL118631 — Ki = 0.71 nM 9.15
CHEMBL411626 — Ki = 0.8318 nM 9.08
CHEMBL411626 — Ki = 0.83 nM 9.08
CHEMBL252949 — Ki = 0.94 nM 9.03
CHEMBL120669 — Ki = 1.27 nM 8.90
CHEMBL120669 — Ki = 1.259 nM 8.90
CHEMBL136120 — Ki = 1.5 nM 8.82
CHEMBL336670 — Ki = 1.75 nM 8.76
CHEMBL108392 — Ki = 1.82 nM 8.74
CHEMBL108392 — Ki = 1.8 nM 8.74
CHEMBL239840 — Ki = 2.188 nM 8.66
CHEMBL239840 — Ki = 2.17 nM 8.66
CHEMBL252742 — Ki = 2.7 nM 8.57
CHEMBL398905 — Ki = 3.9 nM 8.41
CHEMBL138772 — Ki = 4.5 nM 8.35
CHEMBL434351 — Ki = 6.8 nM 8.17
CHEMBL205888 — Ki = 8.26 nM 8.08
CHEMBL205888 — Ki = 8.318 nM 8.08
CHEMBL252536 — Ki = 10.9 nM 7.96
CHEMBL381492 — Ki = 11.75 nM 7.93
CHEMBL381492 — Ki = 11.73 nM 7.93
CHEMBL119592 — Ki = 12.3 nM 7.91
CHEMBL276083 — Ki = 14.0 nM 7.85
CHEMBL118028 — Ki = 17.3 nM 7.76
CHEMBL102270 — Ki = 19.0 nM 7.72
CHEMBL418555 — Ki = 21.88 nM 7.66
CHEMBL67464 — Ki = 22.0 nM 7.66
CHEMBL418555 — Ki = 21.7 nM 7.66
CHEMBL67464 — Ki = 21.88 nM 7.66
CHEMBL206859 — Ki = 27.9 nM 7.55
CHEMBL206859 — Ki = 28.18 nM 7.55
CHEMBL325135 — Ki = 32.3 nM 7.49
CHEMBL325135 — Ki = 32.36 nM 7.49
CHEMBL267227 DELTA-8-TETRAHYDROCANNABINOL Ki = 47.6 nM 7.32
CHEMBL267227 DELTA-8-TETRAHYDROCANNABINOL Ki = 47.86 nM 7.32
CHEMBL322112 — Ki = 56.9 nM 7.25
CHEMBL205908 — Ki = 57.54 nM 7.24