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Assay Detail

CHEMBL925271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of MCSF-independent mouse NSO cells
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type NSO
Confidence 1 — Organism
Curated By Autocuration

Target

NSO (CHEMBL615003) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis of novel anilinoquinolines as c-fms inhibitors.
Smalley TL, Chamberlain SD, Mills WY, Musso DL, Randhawa SA, Ray JA, Samano V, Frick L.
Bioorg Med Chem Lett (2007) 17 : 6257 -6260
PubMed 17870531 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 4.83 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL443587 — — 1 5.40
CHEMBL249960 — — 1 5.10
CHEMBL250160 — — 1 5.10
CHEMBL251174 — — 1 5.10
CHEMBL250161 — — 1 5.10
CHEMBL250362 — — 1 5.10
CHEMBL399647 — — 1 5.00
CHEMBL428228 — — 1 5.00
CHEMBL249137 — — 1 5.00
CHEMBL249371 — — 1 5.00
CHEMBL250571 — — 1 5.00
CHEMBL249573 — — 1 5.00
CHEMBL250774 — — 1 5.00
CHEMBL249169 — — 1 4.92
CHEMBL249545 — — 1 4.89
CHEMBL399703 — — 1 4.89
CHEMBL398469 — — 1 4.89
CHEMBL249170 — — 1 4.80
CHEMBL401420 — — 1 4.70
CHEMBL250775 — — 1 4.70
CHEMBL250364 — — 1 4.70
CHEMBL251367 — — 1 4.60
CHEMBL251173 — — 1 4.60
CHEMBL249163 — — 1 4.50
CHEMBL249752 — — 1 4.50
CHEMBL248930 — — 1 4.50
CHEMBL248740 — — 1 4.50
CHEMBL248931 — — 1 4.50
CHEMBL400288 — — 1 4.40
CHEMBL399441 — — 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL443587 — IC50 = 4000.0 nM 5.40
CHEMBL249960 — IC50 = 8000.0 nM 5.10
CHEMBL250160 — IC50 = 8000.0 nM 5.10
CHEMBL251174 — IC50 = 8000.0 nM 5.10
CHEMBL250161 — IC50 = 8000.0 nM 5.10
CHEMBL250362 — IC50 = 8000.0 nM 5.10
CHEMBL399647 — IC50 = 10000.0 nM 5.00
CHEMBL428228 — IC50 = 10000.0 nM 5.00
CHEMBL249137 — IC50 = 10000.0 nM 5.00
CHEMBL249371 — IC50 = 10000.0 nM 5.00
CHEMBL250571 — IC50 = 10000.0 nM 5.00
CHEMBL249573 — IC50 = 10000.0 nM 5.00
CHEMBL250774 — IC50 = 10000.0 nM 5.00
CHEMBL249169 — IC50 = 12000.0 nM 4.92
CHEMBL398469 — IC50 = 13000.0 nM 4.89
CHEMBL249545 — IC50 = 13000.0 nM 4.89
CHEMBL399703 — IC50 = 13000.0 nM 4.89
CHEMBL249170 — IC50 = 16000.0 nM 4.80
CHEMBL401420 — IC50 = 20000.0 nM 4.70
CHEMBL250775 — IC50 = 20000.0 nM 4.70
CHEMBL250364 — IC50 = 20000.0 nM 4.70
CHEMBL251367 — IC50 = 25000.0 nM 4.60
CHEMBL251173 — IC50 = 25000.0 nM 4.60
CHEMBL249163 — IC50 = 32000.0 nM 4.50
CHEMBL248931 — IC50 = 32000.0 nM 4.50
CHEMBL248740 — IC50 = 32000.0 nM 4.50
CHEMBL249752 — IC50 = 32000.0 nM 4.50
CHEMBL248930 — IC50 = 32000.0 nM 4.50
CHEMBL400288 — IC50 = 40000.0 nM 4.40
CHEMBL399441 — IC50 = 50000.0 nM 4.30
CHEMBL249138 — IC50 > 20000.0 nM -
CHEMBL249139 — IC50 > 20000.0 nM -
CHEMBL249751 — IC50 > 32000.0 nM -
CHEMBL400289 — IC50 > 50000.0 nM -
CHEMBL250572 — IC50 > 20000.0 nM -
CHEMBL249544 — IC50 > 16000.0 nM -
CHEMBL248933 — IC50 > 50000.0 nM -
CHEMBL399739 — IC50 > 32000.0 nM -
CHEMBL249781 — IC50 > 50000.0 nM -
CHEMBL398920 — IC50 > 40000.0 nM -
CHEMBL249377 — IC50 > 50000.0 nM -
CHEMBL399702 — IC50 > 20000.0 nM -
CHEMBL249574 — IC50 > 50000.0 nM -
CHEMBL399117 — IC50 > 50000.0 nM -
CHEMBL249779 — IC50 > 32000.0 nM -
CHEMBL399932 — IC50 > 32000.0 nM -
CHEMBL399118 — IC50 > 20000.0 nM -