Assay Detail
Binding
CHEMBL925647
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Binding affinity at human prostaglandin EP2 receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.71 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.31 |
| CHEMBL271896 | BUTAPROST | 2.0 | 1 | 6.96 |
| CHEMBL400447 | — | — | 1 | 6.25 |
| CHEMBL250153 | — | — | 1 | 6.12 |
| CHEMBL398827 | — | — | 1 | 5.69 |
| CHEMBL249136 | — | — | 1 | 5.66 |
| CHEMBL404414 | — | — | 1 | 5.63 |
| CHEMBL249954 | — | — | 1 | 5.61 |
| CHEMBL249341 | — | — | 1 | 5.56 |
| CHEMBL249539 | — | — | 1 | 5.55 |
| CHEMBL249953 | — | — | 1 | 5.51 |
| CHEMBL404413 | — | — | 1 | 5.36 |
| CHEMBL249538 | — | — | 1 | 5.26 |
| CHEMBL249744 | — | — | 1 | 5.25 |
| CHEMBL249540 | — | — | 1 | 5.22 |
| CHEMBL249342 | — | — | 1 | 5.21 |
| CHEMBL400446 | — | — | 1 | 5.20 |
| CHEMBL249745 | — | — | 1 | 5.08 |
| CHEMBL249952 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL271896 | BUTAPROST | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL400447 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL250153 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL398827 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL249136 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL404414 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL249954 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL249341 | — | Ki | = | 2760.0 | nM | 5.56 |
| CHEMBL249539 | — | Ki | = | 2830.0 | nM | 5.55 |
| CHEMBL249953 | — | Ki | = | 3070.0 | nM | 5.51 |
| CHEMBL404413 | — | Ki | = | 4410.0 | nM | 5.36 |
| CHEMBL249538 | — | Ki | = | 5450.0 | nM | 5.26 |
| CHEMBL249744 | — | Ki | = | 5690.0 | nM | 5.25 |
| CHEMBL249540 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL249342 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL400446 | — | Ki | = | 6290.0 | nM | 5.20 |
| CHEMBL249745 | — | Ki | = | 8340.0 | nM | 5.08 |
| CHEMBL249952 | — | Ki | = | 9200.0 | nM | 5.04 |