Assay Detail
Functional
CHEMBL925650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human prostaglandin EP4 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.85 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249953 | — | — | 1 | 10.00 |
| CHEMBL249744 | — | — | 1 | 9.70 |
| CHEMBL249538 | — | — | 1 | 9.70 |
| CHEMBL249136 | — | — | 1 | 8.30 |
| CHEMBL404413 | — | — | 1 | 6.56 |
| CHEMBL398827 | — | — | 1 | - |
| CHEMBL249952 | — | — | 1 | - |
| CHEMBL249341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249953 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL249744 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL249538 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL249136 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL404413 | — | EC50 | = | 277.0 | nM | 6.56 |
| CHEMBL398827 | — | EC50 | - | — | - | |
| CHEMBL249952 | — | EC50 | - | — | - | |
| CHEMBL249341 | — | EC50 | - | — | - |