Assay Detail
Binding
CHEMBL925700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 protease
8
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.55 | 10.85 |
| IC50 | 2 | 8.74 | 8.74 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469086 | — | — | 1 | 10.85 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.80 |
| CHEMBL254841 | — | — | 1 | 10.00 |
| CHEMBL315403 | — | — | 1 | 8.74 |
| CHEMBL254349 | — | — | 2 | 8.74 |
| CHEMBL254419 | — | — | 1 | - |
| CHEMBL168640 | PPL-100 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469086 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL254841 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL315403 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL254349 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL254349 | — | Ki | = | 0.0045 | nM | - |
| CHEMBL254419 | — | Activity | < | 20.0 | nM | - |
| CHEMBL168640 | PPL-100 | Activity | < | 20.0 | nM | - |