Assay Detail
Binding
CHEMBL925936
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Binding affinity to human MC1bR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.54 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257759 | — | — | 1 | 6.51 |
| CHEMBL429854 | — | — | 1 | 6.16 |
| CHEMBL254589 | — | — | 1 | 5.87 |
| CHEMBL403420 | — | — | 1 | 5.18 |
| CHEMBL402769 | — | — | 1 | 4.79 |
| CHEMBL254757 | — | — | 1 | 4.70 |
| CHEMBL255286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257759 | — | IC50 | = | 311.6 | nM | 6.51 |
| CHEMBL429854 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL254589 | — | IC50 | = | 1339.0 | nM | 5.87 |
| CHEMBL403420 | — | IC50 | = | 6586.0 | nM | 5.18 |
| CHEMBL402769 | — | IC50 | = | 16370.0 | nM | 4.79 |
| CHEMBL254757 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL255286 | — | IC50 | = | 173500.0 | nM | - |