Assay Detail
Functional
CHEMBL925940
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Agonist activity at human MC1bR expressed in CHO cells assessed as cAMP release
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.19 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429854 | — | — | 1 | 6.56 |
| CHEMBL254589 | — | — | 1 | 6.04 |
| CHEMBL255286 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429854 | — | EC50 | = | 273.6 | nM | 6.56 |
| CHEMBL254589 | — | EC50 | = | 905.0 | nM | 6.04 |
| CHEMBL255286 | — | EC50 | = | 1065.0 | nM | 5.97 |