Assay Detail
Functional
CHEMBL926026
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Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.14 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256714 | — | — | 1 | 7.82 |
| CHEMBL113051 | GIMATECAN | 2.0 | 1 | 7.70 |
| CHEMBL111767 | — | — | 1 | 7.52 |
| CHEMBL255713 | — | — | 1 | 7.43 |
| CHEMBL74190 | HOMOCAMPTOTHECIN | — | 1 | 7.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.75 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 6.66 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256714 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL113051 | GIMATECAN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL111767 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL255713 | — | IC50 | = | 36.8 | nM | 7.43 |
| CHEMBL74190 | HOMOCAMPTOTHECIN | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 1180.0 | nM | 5.93 |