Assay Detail
Functional
CHEMBL926027
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Antiproliferative activity against human H460 cells after 2 hrs of drug exposure measured after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.28 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402419 | — | — | 1 | 8.74 |
| CHEMBL113051 | GIMATECAN | 2.0 | 1 | 7.82 |
| CHEMBL402505 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402419 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL113051 | GIMATECAN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL402505 | — | IC50 | > | 200.0 | nM | - |