Assay Detail
Binding
CHEMBL926063
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Inhibition of SPP expressed in HEK293 cells in presence of Prl-PP peptide after 30 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.35 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255473 | — | — | 1 | 5.70 |
| CHEMBL302004 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255473 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL302004 | — | IC50 | = | 10000.0 | nM | 5.00 |