Assay Detail
Functional
CHEMBL926173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Probable C-C chemokine receptor type 3 (CHEMBL3406) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.77 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249854 | — | — | 1 | 8.15 |
| CHEMBL250689 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249854 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL250689 | — | IC50 | = | 41.0 | nM | 7.39 |