Assay Detail
Binding
CHEMBL926355
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Inhibition of Toxoplasma gondii DHFR
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.99 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252132 | — | — | 1 | 7.64 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.48 |
| CHEMBL389051 | — | — | 1 | 6.66 |
| CHEMBL252338 | — | — | 1 | 6.57 |
| CHEMBL253795 | — | — | 1 | 6.52 |
| CHEMBL401073 | — | — | 1 | 6.48 |
| CHEMBL252134 | — | — | 1 | 6.46 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 6.37 |
| CHEMBL429308 | — | — | 1 | 5.80 |
| CHEMBL446714 | — | — | 1 | 5.75 |
| CHEMBL253581 | — | — | 1 | 5.46 |
| CHEMBL400304 | — | — | 1 | 5.41 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.17 |
| CHEMBL401074 | — | — | 1 | 4.82 |
| CHEMBL252133 | — | — | 1 | 4.70 |
| CHEMBL253796 | — | — | 1 | 4.62 |
| CHEMBL225180 | — | — | 1 | - |
| CHEMBL400485 | — | — | 1 | - |
| CHEMBL400364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252132 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL389051 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL252338 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL253795 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL401073 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL252134 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL225072 | PEMETREXED | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL429308 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL446714 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL253581 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL400304 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL401074 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL252133 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL253796 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL225180 | — | IC50 | - | — | - | |
| CHEMBL400485 | — | IC50 | - | — | - | |
| CHEMBL400364 | — | IC50 | - | — | - |