Assay Detail
Functional
CHEMBL926382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.01 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399164 | — | — | 1 | 8.81 |
| CHEMBL250552 | — | — | 1 | 8.65 |
| CHEMBL156639 | — | — | 1 | 7.91 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399164 | — | EC50 | = | 1.56 | nM | 8.81 |
| CHEMBL250552 | — | EC50 | = | 2.22 | nM | 8.65 |
| CHEMBL156639 | — | EC50 | = | 12.2 | nM | 7.91 |
| CHEMBL59 | DOPAMINE | EC50 | = | 209.0 | nM | 6.68 |