Assay Detail
Functional
CHEMBL926384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AtT20 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.31 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399164 | — | — | 1 | 10.10 |
| CHEMBL250552 | — | — | 1 | 9.92 |
| CHEMBL156639 | — | — | 1 | 9.16 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399164 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL250552 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL156639 | — | EC50 | = | 0.69 | nM | 9.16 |
| CHEMBL59 | DOPAMINE | EC50 | = | 8.53 | nM | 8.07 |