Assay Detail
Functional
CHEMBL926653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticoagulant activity against human plasma assessed as concentration required to double activated partial thromboplastin time
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
7-fluoroindazoles as potent and selective inhibitors of factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.85 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223042 | — | — | 1 | 5.51 |
| CHEMBL255053 | — | — | 1 | 5.36 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 2 | 5.21 |
| CHEMBL251939 | — | — | 1 | 5.12 |
| CHEMBL399163 | — | — | 1 | 5.00 |
| CHEMBL400504 | — | — | 1 | 4.96 |
| CHEMBL398870 | — | — | 1 | 4.64 |
| CHEMBL252341 | — | — | 1 | 4.33 |
| CHEMBL255052 | — | — | 1 | 4.26 |
| CHEMBL254831 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223042 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL255053 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL206335 | RAZAXABAN | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL251939 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL399163 | — | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL400504 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL206335 | RAZAXABAN | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL398870 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL252341 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL255052 | — | EC50 | = | 55100.0 | nM | 4.26 |
| CHEMBL254831 | — | EC50 | = | 92000.0 | nM | 4.04 |