Assay Detail
Binding
CHEMBL926665
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Inhibition of nitric oxide synthase in mouse BV2 cells assessed as inhibition of LPS-induced NO production
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.33 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399157 | — | — | 1 | 5.92 |
| CHEMBL252112 | — | — | 1 | 5.89 |
| CHEMBL254180 | — | — | 1 | 5.89 |
| CHEMBL398310 | — | — | 1 | 5.85 |
| CHEMBL252316 | — | — | 1 | 5.58 |
| CHEMBL249656 | — | — | 1 | 5.40 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.70 |
| CHEMBL401306 | — | — | 1 | 4.37 |
| CHEMBL399742 | CROTONKININ A | — | 1 | 4.33 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399157 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL252112 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL254180 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL398310 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL252316 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL249656 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL7890 | L-NAME | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL401306 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL399742 | CROTONKININ A | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL365739 | DIPHENYLENEIODONIUM | IC50 | - | — | - |