Assay Detail
Functional
CHEMBL926667
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Growth inhibition of human MiaPaCa2 cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.40 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204347 | — | — | 1 | 6.00 |
| CHEMBL380627 | — | — | 1 | 5.40 |
| CHEMBL203172 | — | — | 1 | 5.22 |
| CHEMBL203173 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204347 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL380627 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL203172 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL203173 | — | IC50 | = | 11000.0 | nM | 4.96 |