Assay Detail

CHEMBL926871

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat amygdala

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Neuronal acetylcholine receptor subunit alpha-7

CHEMBL4980

Anchored from Assay target.

Protein identity Neuronal acetylcholine receptor subunit alpha-7

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Amygdala
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.

Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee KW.
Proc Natl Acad Sci U S A (2007) 104 : 8059 -8064
PubMed 17470817 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.92	7.92
Ki	1	8.35	8.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL429317	AVL-3288	1.0	2	8.35

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL429317	AVL-3288	Ki	=	4.5	nM	8.35
CHEMBL429317	AVL-3288	IC50	=	12.0	nM	7.92