Assay Detail
Binding
CHEMBL926872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-bungarotoxin from alpha-7 nAChR in rat cortex
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.55 | 7.55 |
| Ki | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429317 | AVL-3288 | 1.0 | 2 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429317 | AVL-3288 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL429317 | AVL-3288 | IC50 | = | 28.0 | nM | 7.55 |