Assay Detail
Functional
CHEMBL926886
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Inhibition on cortisol secretion in human NCI-H295 cells after 48 hrs
20
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H295 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.52 | 8.34 |
| logIC50 | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | 4.0 | 2 | 8.34 |
| CHEMBL260402 | IODOMETOMIDATE I-123, R- | 1.0 | 2 | 8.16 |
| CHEMBL261379 | — | — | 2 | 8.05 |
| CHEMBL406437 | — | — | 2 | 7.86 |
| CHEMBL264703 | — | — | 2 | 7.71 |
| CHEMBL406326 | — | — | 2 | 7.49 |
| CHEMBL441731 | — | — | 2 | 7.28 |
| CHEMBL260469 | — | — | 2 | 7.23 |
| CHEMBL408591 | — | — | 2 | 6.87 |
| CHEMBL406436 | — | — | 2 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL681 | ETOMIDATE | IC50 | = | 4.57 | nM | 8.34 |
| CHEMBL260402 | IODOMETOMIDATE I-123, R- | IC50 | = | 6.95 | nM | 8.16 |
| CHEMBL261379 | — | IC50 | = | 8.92 | nM | 8.05 |
| CHEMBL406437 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL264703 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL406326 | — | IC50 | = | 32.1 | nM | 7.49 |
| CHEMBL441731 | — | IC50 | = | 52.2 | nM | 7.28 |
| CHEMBL260469 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL408591 | — | IC50 | = | 135.3 | nM | 6.87 |
| CHEMBL406436 | — | IC50 | = | 592.9 | nM | 6.23 |
| CHEMBL681 | ETOMIDATE | logIC50 | = | 0.66 | — | - |
| CHEMBL406436 | — | logIC50 | = | 2.77 | — | - |
| CHEMBL406326 | — | logIC50 | = | 1.51 | — | - |
| CHEMBL260469 | — | logIC50 | = | 1.96 | — | - |
| CHEMBL264703 | — | logIC50 | = | 1.45 | — | - |
| CHEMBL408591 | — | logIC50 | = | 2.21 | — | - |
| CHEMBL261379 | — | logIC50 | = | 1.11 | — | - |
| CHEMBL260402 | IODOMETOMIDATE I-123, R- | logIC50 | = | 0.84 | — | - |
| CHEMBL441731 | — | logIC50 | = | 1.72 | — | - |
| CHEMBL406437 | — | logIC50 | = | 1.14 | — | - |