Assay Detail
Binding
CHEMBL926889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 integrase using labelled U5A/U5B double stranded DNA substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.55 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260778 | — | — | 1 | 7.58 |
| CHEMBL261703 | — | — | 1 | 7.52 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | - |
| CHEMBL414850 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260778 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL261703 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | - | — | - | |
| CHEMBL414850 | — | IC50 | - | — | - |