Assay Detail
Binding
CHEMBL927006
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Inhibition of HCV 1b NS5B RNA polymerase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.81 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253752 | — | — | 1 | 7.60 |
| CHEMBL403046 | — | — | 1 | 7.57 |
| CHEMBL176058 | — | — | 1 | 7.50 |
| CHEMBL429676 | — | — | 1 | 7.22 |
| CHEMBL254968 | — | — | 1 | 6.96 |
| CHEMBL403067 | — | — | 1 | 6.89 |
| CHEMBL255107 | — | — | 1 | 6.89 |
| CHEMBL404096 | — | — | 1 | 6.80 |
| CHEMBL258423 | — | — | 1 | 6.50 |
| CHEMBL404677 | — | — | 1 | 6.07 |
| CHEMBL253960 | — | — | 1 | 6.01 |
| CHEMBL257566 | — | — | 1 | 5.66 |
| CHEMBL401825 | — | — | 1 | - |
| CHEMBL404663 | — | — | 1 | - |
| CHEMBL403650 | — | — | 1 | - |
| CHEMBL401974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253752 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL403046 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL176058 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL429676 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL254968 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL403067 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL255107 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL404096 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL258423 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL404677 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL253960 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL257566 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL401825 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL404663 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL403650 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL401974 | — | IC50 | < | 10.0 | nM | - |