Assay Detail
Functional
CHEMBL927007
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Antiviral activity against HCV 1b in human Huh7/C24 cells after 72 hrs by replicon cell assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.04 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401825 | — | — | 1 | 8.30 |
| CHEMBL403650 | — | — | 1 | 8.30 |
| CHEMBL401974 | — | — | 1 | 8.07 |
| CHEMBL404663 | — | — | 1 | 7.92 |
| CHEMBL403046 | — | — | 1 | 7.72 |
| CHEMBL253752 | — | — | 1 | 7.66 |
| CHEMBL404096 | — | — | 1 | 7.02 |
| CHEMBL429676 | — | — | 1 | 6.92 |
| CHEMBL254968 | — | — | 1 | 6.72 |
| CHEMBL255107 | — | — | 1 | 6.48 |
| CHEMBL403067 | — | — | 1 | 6.42 |
| CHEMBL253960 | — | — | 1 | 5.28 |
| CHEMBL257566 | — | — | 1 | 4.77 |
| CHEMBL404677 | — | — | 1 | - |
| CHEMBL258423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401825 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL403650 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL401974 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL404663 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL403046 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL253752 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL404096 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL429676 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL254968 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL255107 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL403067 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL253960 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL257566 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL404677 | — | EC50 | - | — | - | |
| CHEMBL258423 | — | EC50 | - | — | - |