Assay Detail
Binding
CHEMBL927019
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Inhibition of glycosomal Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.90 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200262 | — | — | 1 | 5.37 |
| CHEMBL370662 | — | — | 1 | 4.97 |
| CHEMBL55886 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200262 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL370662 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL55886 | — | Ki | = | 43900.0 | nM | 4.36 |