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Assay Detail

CHEMBL927172

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Binding
Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Coagulation factor VIII (CHEMBL3143)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V.
Segers K, Sperandio O, Sack M, Fischer R, Miteva MA, Rosing J, Nicolaes GA, Villoutreix BO.
Proc Natl Acad Sci U S A (2007) 104 : 12697 -12702
PubMed 17646652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.08 5.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1614804 1 5.11
CHEMBL261865 1 5.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1614804 IC50 = 7800.0 nM 5.11
CHEMBL261865 IC50 = 8900.0 nM 5.05