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Assay Detail

CHEMBL927253

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Binding
Inhibition of influenza A/N1/PR/8/34 neuraminidase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuraminidase (CHEMBL6135)
Type SINGLE PROTEIN
Organism Influenza A virus

Publication

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.
Krueger AC, Xu Y, Kati WM, Kempf DJ, Maring CJ, McDaniel KF, Molla A, Montgomery D, Kohlbrenner WE.
Bioorg Med Chem Lett (2008) 18 : 1692 -1695
PubMed 18242993 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 7.73 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222813 ZANAMIVIR 4.0 1 10.22
CHEMBL1229 OSELTAMIVIR 4.0 1 10.00
CHEMBL473062 1 9.68
CHEMBL251787 1 8.89
CHEMBL253410 1 8.28
CHEMBL253625 1 8.00
CHEMBL254883 1 7.95
CHEMBL253839 1 7.94
CHEMBL398740 1 7.90
CHEMBL400495 1 7.85
CHEMBL254884 1 7.76
CHEMBL398739 1 7.74
CHEMBL254679 1 7.70
CHEMBL398738 1 7.68
CHEMBL400133 1 7.64
CHEMBL399060 1 7.60
CHEMBL253409 1 7.28
CHEMBL251786 1 7.26
CHEMBL254885 1 7.25
CHEMBL253621 1 7.23
CHEMBL399943 1 7.22
CHEMBL399062 1 7.03
CHEMBL445672 1 6.97
CHEMBL428241 1 6.84
CHEMBL400552 1 6.75
CHEMBL370047 1 6.68
CHEMBL399061 1 6.67
CHEMBL401373 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222813 ZANAMIVIR Ki = 0.06 nM 10.22
CHEMBL1229 OSELTAMIVIR Ki = 0.1 nM 10.00
CHEMBL473062 Ki = 0.21 nM 9.68
CHEMBL251787 Ki = 1.3 nM 8.89
CHEMBL253410 Ki = 5.3 nM 8.28
CHEMBL253625 Ki = 10.0 nM 8.00
CHEMBL254883 Ki = 11.3 nM 7.95
CHEMBL253839 Ki = 11.5 nM 7.94
CHEMBL398740 Ki = 12.7 nM 7.90
CHEMBL400495 Ki = 14.0 nM 7.85
CHEMBL254884 Ki = 17.3 nM 7.76
CHEMBL398739 Ki = 18.4 nM 7.74
CHEMBL254679 Ki = 19.8 nM 7.70
CHEMBL398738 Ki = 21.0 nM 7.68
CHEMBL400133 Ki = 23.0 nM 7.64
CHEMBL399060 Ki = 25.0 nM 7.60
CHEMBL253409 Ki = 53.0 nM 7.28
CHEMBL251786 Ki = 55.0 nM 7.26
CHEMBL254885 Ki = 56.0 nM 7.25
CHEMBL253621 Ki = 59.0 nM 7.23
CHEMBL399943 Ki = 60.0 nM 7.22
CHEMBL399062 Ki = 94.0 nM 7.03
CHEMBL445672 Ki = 108.0 nM 6.97
CHEMBL428241 Ki = 145.0 nM 6.84
CHEMBL400552 Ki = 180.0 nM 6.75
CHEMBL370047 Ki = 210.0 nM 6.68
CHEMBL399061 Ki = 212.0 nM 6.67
CHEMBL401373 Ki = 303.0 nM 6.52