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Assay Detail

CHEMBL927483

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Binding
Binding affinity at human LXRbeta
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Hu B, Quinet E, Unwalla R, Collini M, Jetter J, Dooley R, Andraka D, Nogle L, Savio D, Halpern A, Goos-Nilsson A, Wilhelmsson A, Nambi P, Wrobel J.
Bioorg Med Chem Lett (2008) 18 : 54 -59
PubMed 18023179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.97 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL214719 1 8.70
CHEMBL404469 1 8.70
CHEMBL403418 1 8.70
CHEMBL254539 1 8.70
CHEMBL254945 1 8.52
CHEMBL404468 1 8.40
CHEMBL253521 1 8.40
CHEMBL254333 1 8.30
CHEMBL403958 1 8.30
CHEMBL253311 1 8.30
CHEMBL216645 1 8.15
CHEMBL62136 T091317 1 8.05
CHEMBL254541 1 8.00
CHEMBL442437 1 8.00
CHEMBL404265 1 7.96
CHEMBL253731 1 7.82
CHEMBL254542 1 7.58
CHEMBL253312 1 7.46
CHEMBL253398 1 7.17
CHEMBL253730 1 7.09
CHEMBL404036 1 6.66
CHEMBL254335 1 6.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL214719 IC50 = 2.0 nM 8.70
CHEMBL404469 IC50 = 2.0 nM 8.70
CHEMBL403418 IC50 = 2.0 nM 8.70
CHEMBL254539 IC50 = 2.0 nM 8.70
CHEMBL254945 IC50 = 3.0 nM 8.52
CHEMBL404468 IC50 = 4.0 nM 8.40
CHEMBL253521 IC50 = 4.0 nM 8.40
CHEMBL254333 IC50 = 5.0 nM 8.30
CHEMBL403958 IC50 = 5.0 nM 8.30
CHEMBL253311 IC50 = 5.0 nM 8.30
CHEMBL216645 IC50 = 7.0 nM 8.15
CHEMBL62136 T091317 IC50 = 9.0 nM 8.05
CHEMBL254541 IC50 = 10.0 nM 8.00
CHEMBL442437 IC50 = 10.0 nM 8.00
CHEMBL404265 IC50 = 11.0 nM 7.96
CHEMBL253731 IC50 = 15.0 nM 7.82
CHEMBL254542 IC50 = 26.0 nM 7.58
CHEMBL253312 IC50 = 35.0 nM 7.46
CHEMBL253398 IC50 = 67.0 nM 7.17
CHEMBL253730 IC50 = 81.0 nM 7.09
CHEMBL404036 IC50 = 219.0 nM 6.66
CHEMBL254335 IC50 = 473.0 nM 6.33