Assay Detail
Binding
CHEMBL927484
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Binding affinity at human LXRalpha
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.36 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254542 | — | — | 1 | 8.70 |
| CHEMBL254539 | — | — | 1 | 8.22 |
| CHEMBL214719 | — | — | 1 | 8.00 |
| CHEMBL254945 | — | — | 1 | 7.96 |
| CHEMBL62136 | T091317 | — | 1 | 7.89 |
| CHEMBL403958 | — | — | 1 | 7.80 |
| CHEMBL254333 | — | — | 1 | 7.77 |
| CHEMBL403418 | — | — | 1 | 7.68 |
| CHEMBL404469 | — | — | 1 | 7.68 |
| CHEMBL254541 | — | — | 1 | 7.68 |
| CHEMBL404468 | — | — | 1 | 7.51 |
| CHEMBL216645 | — | — | 1 | 7.33 |
| CHEMBL253521 | — | — | 1 | 7.24 |
| CHEMBL253730 | — | — | 1 | 7.19 |
| CHEMBL253398 | — | — | 1 | 6.95 |
| CHEMBL253311 | — | — | 1 | 6.91 |
| CHEMBL404036 | — | — | 1 | 6.83 |
| CHEMBL253312 | — | — | 1 | 6.80 |
| CHEMBL404265 | — | — | 1 | 6.79 |
| CHEMBL442437 | — | — | 1 | 6.68 |
| CHEMBL254335 | — | — | 1 | 6.28 |
| CHEMBL253731 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254542 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL254539 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL214719 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL254945 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL62136 | T091317 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL403958 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL254333 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL403418 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL404469 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL254541 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL404468 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL216645 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL253521 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL253730 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL253398 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL253311 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL404036 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL253312 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL404265 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL442437 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL254335 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL253731 | — | IC50 | = | 745.0 | nM | 6.13 |