Assay Detail
Functional
CHEMBL927487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human LXRbeta expressed in Huh7 cells by Gal4 transactivation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.37 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214719 | — | — | 1 | 7.05 |
| CHEMBL62136 | T091317 | — | 1 | 6.75 |
| CHEMBL253311 | — | — | 1 | 6.45 |
| CHEMBL253731 | — | — | 1 | 6.21 |
| CHEMBL442437 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214719 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL62136 | T091317 | EC50 | = | 178.0 | nM | 6.75 |
| CHEMBL253311 | — | EC50 | = | 355.0 | nM | 6.45 |
| CHEMBL253731 | — | EC50 | = | 622.0 | nM | 6.21 |
| CHEMBL442437 | — | EC50 | = | 4167.0 | nM | 5.38 |