Assay Detail
Functional
CHEMBL927495
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Effect on SREBP1c gene expression in human HepG2 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.26 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.17 |
| CHEMBL214719 | — | — | 1 | 6.78 |
| CHEMBL253311 | — | — | 1 | 6.58 |
| CHEMBL253731 | — | — | 1 | 5.39 |
| CHEMBL442437 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL214719 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL253311 | — | EC50 | = | 263.0 | nM | 6.58 |
| CHEMBL253731 | — | EC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL442437 | — | EC50 | = | 4050.0 | nM | 5.39 |