Assay Detail
Functional
CHEMBL927675
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Cytotoxicity against mouse L1210 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.70 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421884 | — | — | 1 | 6.52 |
| CHEMBL92270 | — | — | 1 | 6.40 |
| CHEMBL328320 | — | — | 1 | 6.16 |
| CHEMBL89918 | — | — | 1 | 5.75 |
| CHEMBL252138 | — | — | 1 | 5.66 |
| CHEMBL251942 | — | — | 1 | 5.66 |
| CHEMBL398284 | — | — | 1 | 5.29 |
| CHEMBL235360 | — | — | 1 | 5.20 |
| CHEMBL254003 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421884 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL92270 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL328320 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL89918 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL252138 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL251942 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL398284 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL235360 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL254003 | — | IC50 | = | 22200.0 | nM | 4.65 |