Assay Detail
Binding
CHEMBL927677
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Inhibition of PAT assessed as cytotoxicity against CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.54 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92270 | — | — | 1 | 6.40 |
| CHEMBL421884 | — | — | 1 | 6.35 |
| CHEMBL89918 | — | — | 1 | 5.72 |
| CHEMBL252138 | — | — | 1 | 5.64 |
| CHEMBL328320 | — | — | 1 | 5.60 |
| CHEMBL251942 | — | — | 1 | 5.28 |
| CHEMBL235360 | — | — | 1 | 5.11 |
| CHEMBL398284 | — | — | 1 | 5.11 |
| CHEMBL254003 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92270 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL421884 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL89918 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL252138 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL328320 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL251942 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL235360 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL398284 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL254003 | — | IC50 | = | 22200.0 | nM | 4.65 |