Assay Detail
Binding
CHEMBL927686
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Binding affinity to MMP2
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.93 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373532 | — | — | 1 | 8.30 |
| CHEMBL375418 | — | — | 1 | 7.89 |
| CHEMBL251884 | — | — | 1 | 7.89 |
| CHEMBL253920 | — | — | 1 | 7.85 |
| CHEMBL402954 | — | — | 1 | 7.68 |
| CHEMBL403161 | — | — | 1 | 7.62 |
| CHEMBL251847 | — | — | 1 | 7.50 |
| CHEMBL403185 | — | — | 1 | 7.46 |
| CHEMBL252678 | — | — | 1 | 7.43 |
| CHEMBL251865 | — | — | 1 | 7.41 |
| CHEMBL252877 | — | — | 1 | 7.30 |
| CHEMBL252079 | — | — | 1 | 7.30 |
| CHEMBL401870 | — | — | 1 | 7.28 |
| CHEMBL404132 | — | — | 1 | 7.20 |
| CHEMBL446457 | — | — | 1 | 7.07 |
| CHEMBL429669 | — | — | 1 | 6.97 |
| CHEMBL403380 | — | — | 1 | 6.80 |
| CHEMBL221857 | — | — | 1 | 6.71 |
| CHEMBL253256 | — | — | 1 | 6.41 |
| CHEMBL252278 | — | — | 1 | 6.36 |
| CHEMBL219104 | — | — | 1 | 6.35 |
| CHEMBL442443 | — | — | 1 | 6.33 |
| CHEMBL252442 | — | — | 1 | 6.31 |
| CHEMBL252246 | — | — | 1 | 6.02 |
| CHEMBL252081 | — | — | 1 | 5.96 |
| CHEMBL253460 | — | — | 1 | 5.86 |
| CHEMBL404170 | — | — | 1 | 5.60 |
| CHEMBL403022 | — | — | 1 | 5.30 |
| CHEMBL252912 | — | — | 1 | - |
| CHEMBL251848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373532 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL375418 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL251884 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL253920 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL402954 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL403161 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL251847 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL403185 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL252678 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL251865 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL252877 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL252079 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL401870 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL404132 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL446457 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL429669 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL403380 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL221857 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL253256 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL252278 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL219104 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL442443 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL252442 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL252246 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL252081 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL253460 | — | IC50 | = | 1387.0 | nM | 5.86 |
| CHEMBL404170 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL403022 | — | IC50 | = | 4999.0 | nM | 5.30 |
| CHEMBL252912 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL251848 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL404093 | — | IC50 | > | 5000.0 | nM | - |